14.3 Glucose Disposal Agents (GDA)

The 'Traffic Cop' for your metabolism. Mimicking caloric restriction by lowering insulin and activating AMPK.

Metformin

SGLT2

Insulin Sensitivity

Longevity

The Traffic Cop Analogy

Insulin is the Traffic Cop. When he's tired (Resistance), sugar jams up the highway. Metformin gives him a megaphone. SGLT2 Inhibitors open an emergency exit ramp (urine).

Metformin (The Anchor)

Most studied longevity drug (TAME Trial). Activates AMPK (Cleanup mode).

ProsAnti-Cancer, Cheap
ConsBlunts Muscle Growth (mTOR)
RuleNEVER Post-Workout

SGLT2 Inhibitors (The Exit)

"Super-Fasting" pill. Forces body to pee out sugar (~300 cal/day). Induces mild ketosis.

EffectLower Insulin, Weight Loss
RiskUTIs, Dehydration
ExampleCanagliflozin / Empagliflozin

The AMPK / mTOR Seesaw

You cannot destroy (AMPK) and build (mTOR) at the same time. Taking Metformin after lifting weights cancels your gains.Attia has shifted away from Metformin for active individuals for this reason.

Expert Stacks

The "Safe" Stack

For those avoiding Rx drugs.

Berberine (Dihydro-Berberine)
Ceylon Cinnamon
Apple Cider Vinegar (Pre-meal)

The "Rapamycin" Stack

Legendary longevity combo.

Rapamycin (mTOR inhibitor)
Acarbose (Blocks starch breakdown)
Result: Lifespan extension w/o mitochondrial toxicity.

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