Severe Abdominal Pain
Seek medical attention. May indicate pancreatitis or gastroparesis.
Dizziness / Sweating (Hypoglycemia)
EMERGENCY: Consume 50g fast carbohydrates (glucose tabs, juice, soda) immediately. Recheck glucose in 15 min. Seek care if unresponsive.
Hypoglycemia (with insulin or sulfonylurea)
Reduce insulin/sulfonylurea dose when starting GLP-1. Monitor glucose; have fast-acting carbs available.
Severe Hypertension / BP Spike
PT-141 can raise BP. If on BP meds or history of HTN, monitor. Seek care if severe headache or chest pain.
Intense Flushing / Heat
Normal histamine response. Usually subsides in 15–30 minutes. Antihistamine may help if severe.
Flushing / Redness
Common. Typically resolves within 30 min. Stay hydrated.
Flushing / Warmth
Common GH secretagogue response. Subsides quickly.
Increased Hunger
Expected (ghrelin agonist). Plan meals; avoid overeating.
Nausea / Vomiting
Common. Start low dose; titrate slowly. Stay hydrated. Contact provider if severe or persistent.
Nausea / Flushing / Yawning
Common melanocortin response. Usually mild; subsides in 1–2 hours.
Nausea (high dose)
Reduce dose or take with food. Usually transient.
Lethargy / Fatigue
Common in first days. Usually improves; ensure adequate sleep and hydration.
Copper Overload / Metallic Taste
Consider zinc balance; reduce dose or frequency. Check Zn/Cu if persistent.
Severe Nausea
Very common. Start with low dose; build tolerance. Antiemetic may help.
