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5.3 5-Amino-1MQ

Muscle Sparing Agent. The premier oral agent for protecting muscle while in a deep caloric deficit.

Muscle Sparing

Hypertrophy

Fat Loss

Oral

The "White Fat" Killer. 5-Amino-1MQ blocks the NNMT enzyme, preventing the cell from slowing down its metabolism.

🔰 Beginner's Guide: The Fat Cell Shrinker

The ProblemFat cells produce an enzyme (NNMT) that makes them "lazy" and resistant to burning.

The Fix5-Amino-1MQ stops this enzyme, forcing fat cells to wake up. It forces the body to prioritize burning Fat over Muscle.

Deep Dive: NNMT & The NAD+ Sink

Without 5-Amino-1MQ

NNMT Parasite: Drains NAD+ (Fuel) to expand fat cells.
Result: Fat cells grow, metabolism slows (The "Leak").

With 5-Amino-1MQ

Block NNMT: Plugs the leak.
Result: +30–50% Intracellular NAD+. Fat shrinks, Muscle activates.

Synergy: The Gold Standard

Stacking with a GLP-1 (Semaglutide) is elite for Body Recomposition. GLP-1 reduces intake; 5-Amino preserves output (Muscle).

Clinical Protocols

Standard Dose150mg Daily (Oral).

Option A (Steady)50mg with Breakfast, Lunch, and Dinner.

Option B (Simple)150mg all at once in the morning.

Duration: 1-3 months (cutting phase).
Effect: Increased body temp and vascularity within 2 weeks.

❓ FAQ

Does it cause "jitters"?

No. Non-stimulatory. Works on NAD+, not Adrenaline.

Athletic Performance?

Yes. Improves contractile force and recovery speed.

Safe for Liver?

Monitor enzymes if using > 3 months.

🔧 Practical Solutions

High Cost ($150-$200)

Only use when already lean (<15% body fat). Wasted on high body fat (use GLP-1s first).

Energy Swings

Increases BMR. Take with food in AM. Do NOT take pre-bed.

Real-Life Case Study

Subject: The Powerlifter (Male, 210lbs)

Goal:Cut to 198lb class without losing strength. No GLP-1s (fear of weakness).
Protocol:5-Amino-1MQ (150mg) + Tesofensine (250mcg) x 4 weeks.
Results:Dropped 14lbs. Squat strength CONSTANT. "Fuller and harder look."

"Block NNMT, and you liberate NAD+. It's a longevity drug disguised as a fat burner."

— Dr. Seeds

Expert Perspectives on Muscle-Sparing Agents

Dr. Peter Attia

Medicine 3.0 Pioneer

"GLP-1 agonists are arguably the most impactful drugs of the century, but if you lose muscle while on them, you are trading diabetes for frailty. Resistance training is not optional."

Metabolic health and muscle preservation

— Outlive (2023)

Dr. Peter Attia

Medicine 3.0 Pioneer

"If you're on a GLP-1 agonist and not doing resistance training, you're trading metabolic health for frailty. Muscle loss on these drugs is real and preventable with proper training."

GLP-1 agonists and muscle preservation

— The Drive Podcast

Dr. Peter Attia

Medicine 3.0 Pioneer

"The next generation of metabolic therapeutics will be triple agonists like Retatrutide. Combining GLP-1, GIP, and Glucagon activation addresses multiple pathways simultaneously—not just appetite suppression, but actual metabolic rate enhancement."

Future of metabolic therapeutics

— The Drive Podcast

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5.3 5-Amino-1MQ

Muscle Sparing Agent. The premier oral agent for protecting muscle while in a deep caloric deficit.

Muscle Sparing

Hypertrophy

Fat Loss

Oral

The "White Fat" Killer. 5-Amino-1MQ blocks the NNMT enzyme, preventing the cell from slowing down its metabolism.

🔰 Beginner's Guide: The Fat Cell Shrinker

The ProblemFat cells produce an enzyme (NNMT) that makes them "lazy" and resistant to burning.

The Fix5-Amino-1MQ stops this enzyme, forcing fat cells to wake up. It forces the body to prioritize burning Fat over Muscle.

Deep Dive: NNMT & The NAD+ Sink

Without 5-Amino-1MQ

NNMT Parasite: Drains NAD+ (Fuel) to expand fat cells.
Result: Fat cells grow, metabolism slows (The "Leak").

With 5-Amino-1MQ

Block NNMT: Plugs the leak.
Result: +30–50% Intracellular NAD+. Fat shrinks, Muscle activates.

Synergy: The Gold Standard

Stacking with a GLP-1 (Semaglutide) is elite for Body Recomposition. GLP-1 reduces intake; 5-Amino preserves output (Muscle).

Clinical Protocols

Standard Dose150mg Daily (Oral).

Option A (Steady)50mg with Breakfast, Lunch, and Dinner.

Option B (Simple)150mg all at once in the morning.

Duration: 1-3 months (cutting phase).
Effect: Increased body temp and vascularity within 2 weeks.

❓ FAQ

Does it cause "jitters"?

No. Non-stimulatory. Works on NAD+, not Adrenaline.

Athletic Performance?

Yes. Improves contractile force and recovery speed.

Safe for Liver?

Monitor enzymes if using > 3 months.

🔧 Practical Solutions

High Cost ($150-$200)

Only use when already lean (<15% body fat). Wasted on high body fat (use GLP-1s first).

Energy Swings

Increases BMR. Take with food in AM. Do NOT take pre-bed.

Real-Life Case Study

Subject: The Powerlifter (Male, 210lbs)

Goal:Cut to 198lb class without losing strength. No GLP-1s (fear of weakness).
Protocol:5-Amino-1MQ (150mg) + Tesofensine (250mcg) x 4 weeks.
Results:Dropped 14lbs. Squat strength CONSTANT. "Fuller and harder look."

"Block NNMT, and you liberate NAD+. It's a longevity drug disguised as a fat burner."

— Dr. Seeds

Expert Perspectives on Muscle-Sparing Agents

Dr. Peter Attia

Medicine 3.0 Pioneer

"GLP-1 agonists are arguably the most impactful drugs of the century, but if you lose muscle while on them, you are trading diabetes for frailty. Resistance training is not optional."

Metabolic health and muscle preservation

— Outlive (2023)

Dr. Peter Attia

Medicine 3.0 Pioneer

"If you're on a GLP-1 agonist and not doing resistance training, you're trading metabolic health for frailty. Muscle loss on these drugs is real and preventable with proper training."

GLP-1 agonists and muscle preservation

— The Drive Podcast

Dr. Peter Attia

Medicine 3.0 Pioneer

"The next generation of metabolic therapeutics will be triple agonists like Retatrutide. Combining GLP-1, GIP, and Glucagon activation addresses multiple pathways simultaneously—not just appetite suppression, but actual metabolic rate enhancement."

Future of metabolic therapeutics

— The Drive Podcast

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