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Understanding GH secretagogues, timing, and strategic use for longevity and performance
Growth Hormone (GH) is produced by your pituitary gland and controls:
The Problem: GH production declines ~15% per decade after age 30. By 60, you may have only 20% of youthful levels.
The Solution: GH secretagogues stimulate your pituitary to release more of YOUR OWN GH—much safer than injecting synthetic HGH.
Tells the pituitary to release GH. Works like pressing the gas pedal.
Stimulates GH through the ghrelin pathway. Amplifies the signal.
| Peptide | Type | GH Increase | Hunger | Cortisol | Best For |
|---|---|---|---|---|---|
| Ipamorelin | GHRP | ++ | None | None | Beginners, Sleep, Recovery |
| CJC-1295 (no DAC) | GHRH | ++ | None | None | Combining with GHRP |
| CJC-1295 (with DAC) | GHRH | +++ | None | Slight | Once-weekly dosing |
| Tesamorelin | GHRH | +++ | None | None | Fat loss, FDA-approved |
| GHRP-2 | GHRP | +++ | Moderate | Slight | Maximum GH output |
| GHRP-6 | GHRP | +++ | Strong | Moderate | Bulking, Appetite increase |
| MK-677 | Oral | ++ | Moderate | None | Convenience, Long-term |
Safe introduction to GH peptides
Synergistic combination for optimal results
Maximum GH optimization for experienced users
GH secretion follows circadian patterns. Optimize timing for maximum effect:
Amplifies natural nocturnal GH pulse. Enhanced deep sleep.
Enhances fat oxidation. Take 30+ minutes before food.
Avoid: Eating within 2 hours of dosing. Insulin blunts GH release significantly.
Optimal Range: 150-250 ng/mL for most individuals
Anti-Aging Zone: 180-220 ng/mL - balances benefits with longevity
Performance Zone: 220-280 ng/mL - more aggressive, monitor closely
Caution: Levels >300 ng/mL may increase cancer risk long-term
Testing Schedule: Baseline before starting, 4 weeks in, then every 8-12 weeks. Draw blood fasted, 3-4 hours after morning dose or before evening dose.
No. GH secretagogues stimulate your pituitary to release YOUR OWN growth hormone. This maintains your body's natural feedback loops and is much safer than exogenous HGH, which suppresses natural production.
Sleep improvements: 1-2 weeks. Recovery benefits: 2-4 weeks. Body composition changes: 6-12 weeks. Be patient—GH peptides work gradually but sustainably.
Cycling (5 on/2 off weekly, plus periodic longer breaks) helps prevent pituitary desensitization. After 12-16 weeks, take 4-6 weeks off before resuming. Some use MK-677 during "off" periods.
Yes. GH peptides stack well with BPC-157/TB-500 for healing, Tesamorelin for fat loss, or bioregulators like Epitalon for longevity. Avoid combining multiple GH peptides that work on the same pathway.
Use our tools to calculate dosing and track your progress