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The 'Natural' GH Boosters. Choosing between injectable peptides and oral alternatives.
Three paths to elevated Growth Hormone: CJC-1295/Ipamorelin (The Gold Standard),MK-677 (The Convenient), and Hexarelin (The Powerful). Each has trade-offs between potency, convenience, and side effects.
| Feature | CJC-1295 + Ipamorelin | Ipamorelin Solo | MK-677 | Hexarelin |
|---|---|---|---|---|
| Mechanism | GHRH + GHRP | GHRP only | Ghrelin Mimetic | GHRP (Potent) |
| Route | SubQ Injection | SubQ Injection | Oral Pill | SubQ Injection |
| Half-Life | 2-4 hours (No DAC) | 2 hours | 24 hours | 30 minutes |
| GH Pulse | Physiological (Natural) | Physiological | Sustained Elevation | Massive Spike |
| Hunger Effect | None | None | Extreme (Major Issue) | Moderate |
| Cortisol Impact | Neutral | Neutral | Raises (Problem) | Slight Increase |
| Prolactin Impact | Neutral | Neutral | Raises (Problem) | Neutral |
| Best For | Anti-Aging (Gold Standard) | Sleep Quality | Mass Building (Trade-offs) | Peak Performance |
The Clean, Physiological Release
CJC-1295 (No DAC): GHRH analog that amplifies the pituitary's natural GH release.Ipamorelin: GHRP that triggers the release pulse. Together, they create a synergistic physiological GH pulse (similar to natural sleep) without hunger or cortisol spikes.
Minimal. Possible injection site redness (histamine). Rare water retention in first week.
The "Dirty" Secretagogue
Oral ghrelin mimetic that binds to ghrelin receptors in the brain, triggering massive GH release. The "convenience" of oral dosing comes with significant trade-offs: extreme hunger, insulin resistance, cortisol elevation, and prolactin increase.
Goal: Better sleep, recovery, skin quality without side effects.
CJC-1295 + Ipamorelin (100/100mcg nightly)
Goal: Improve deep sleep without complex protocols.
Ipamorelin solo (200mcg nightly)
Goal: Maximum muscle gain, can handle hunger/cortisol.
MK-677 (20mg nightly) + Metformin (for insulin)
CJC-1295 (100mcg) + Ipamorelin (100mcg) + Mod-GRF (100mcg) - Triple synergy for maximum pulse.
Ipamorelin (200mcg) + DSIP (300mcg) - For deep sleep optimization.
MK-677 + CJC/Ipa - Overstimulation, massive hunger, cortisol spike.
Hexarelin + MK-677 - Extreme hunger, insulin crash, poor sleep.
Subject: Male, 45. Wanted better sleep and recovery without weight gain.
Protocol: Started with MK-677 (oral convenience). Hunger became unmanageable, gained 10lbs in 4 weeks. Switched to CJC/Ipa stack.
Result: Sleep quality improved significantly. Zero hunger. Lost the 10lbs in 6 weeks. Now maintains lean physique with better recovery.
MK-677 causes significant insulin resistance. If using MK-677, you MUST: - Monitor glucose (CGM recommended) - Consider Metformin (500mg twice daily) - Avoid high-carb meals 2h post-dose
Hexarelin is very potent but causes rapid receptor downregulation. Cycle: 2 weeks on, 2 weeks off maximum. Do NOT use daily for extended periods.
Growth Hormone can accelerate tumor growth. DO NOT use any GH secretagogue if you have active cancer or are in remission (<5 years). Consult oncologist first.