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Chronic Inflammatory Response Syndrome: Navigating the biotoxin landscape.
CIRS (Chronic Inflammatory Response Syndrome) is a multi-system illness caused by biotoxins, primarily from water-damaged buildings. ~25% of the population has genetic susceptibility (HLA-DR). These individuals cannot clear mycotoxins, leading to systemic inflammation.
Leave water-damaged building. No treatment works if exposure continues.
Bile acid sequestrants bind mycotoxins in gut. CSM 4g 4x/day for 1-3 months.
Treat nasal staph colonization with BEG spray if present.
Address ADH, cortisol, VIP, MSH as needed with specific interventions.
| Peptide | Mechanism | Dose | Role in CIRS |
|---|---|---|---|
| VIP | Anti-inflammatory, regulatory | 50mcg nasal 4x/day | Final step in Shoemaker |
| BPC-157 | Gut healing, anti-inflammatory | 500mcg oral 2x/day | Gut repair, binder tolerance |
| KPV | ฮฑ-MSH fragment | 300mcg oral 2x/day | MSH pathway support |
| Thymosin ฮฑ1 | Immune modulation | 1.6mg SubQ 2x/week | Immune rebalancing |
Initial binder phase, some feel worse (die-off).
Cognitive improvement, energy starting to return.
Significant improvement in most symptoms.
Full recovery possible with diligent protocol.