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Optimizing the body's primary detoxification factory.
Your primary detoxification organ processes toxins through Phase I (activation) and Phase II (conjugation). Glutathione is the master antioxidant and primary Phase II conjugator. Supporting these pathways is essential for effective detox.
Cytochrome P450 enzymes modify toxins, often creating MORE reactive intermediates.
Support: B vitamins, Milk Thistle
Often more toxic than parent compounds—must be quickly processed. Danger zone if Phase II is slow.
Glutathione, sulfation, glucuronidation attach to metabolites for excretion.
Support: NAC, glycine, sulfur foods
Water-soluble conjugates excreted via bile → stool or kidneys → urine.
| Method | Form | Dose | Notes |
|---|---|---|---|
| NAC | Precursor | 600-1800mg | Cost-effective, proven |
| Liposomal GSH | Direct | 500-1000mg | Better absorption |
| IV Glutathione | Direct | 1-2g | 100% Bioavailability |
| Glycine | Precursor | 3-5g | Rate-limiting for GSH |
| Whey Protein | Natural source | 20-40g | Cysteine source |
If Phase I is faster than Phase II, toxic intermediates accumulate. Support Phase II BEFORE pushing Phase I.