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The 'Wolverine Stack'. Synergistic peptides for soft tissue, gut, and neurological repair. Reduce healing time by 50%.
The gold standard for injury recovery. BPC-157 (The Foreman) signals the repair, while TB-500 (The Workers) enables cell migration to the site. Together, they can reduce healing time by roughly 50%.
The Concern: BPC-157 promotes angiogenesis (new blood vessel growth). Tumors need blood vessels to grow. Therefore, theoretically, BPC-157 could accelerate existing cancer.
ACL, Rotator Cuff, Tennis Elbow
Local BPC signals repair site. TB-500 enables cell migration.
Leaky Gut, IBS, Crohn's
Oral BPC directly heals gut lining. Must be Arg-Salt version (stable in gastric acid).
Hamstring, Calf, Pec Tears
TB-500 is primary for muscle. Enables cell migration to tear site.
Systemic vs Local Injection
Systemic Only (Long Half-Life)
TB-500 is SYSTEMIC. It doesn't matter where you inject (belly fat is fine). It works throughout the body via bloodstream. Local injection near injury offers no advantage.
BPC-157 (250mcg 2x/day) + TB-500 (2.5mg 2x/week)
The gold standard for tendon/ligament injuries. 50% faster healing time.
BPC-157 (Oral 250mcg 2x/day) + GHK-Cu (2mg SubQ daily)
Gut lining repair + collagen synthesis. Essential for IBD/IBS.
BPC-157 (500mcg systemic) + ARA-290 (4mg SubQ daily)
For neuropathy, sciatica, nerve damage. Both peptides support nerve regeneration.
BPC-157 + High-dose NSAIDs (Ibuprofen, Naproxen)
NSAIDs suppress inflammation that BPC-157 uses for signaling. Counterproductive.
TB-500 + High-dose Corticosteroids (Prednisone)
Corticosteroids impair cell migration. TB-500 needs migration to work.
Note: These timelines assume proper rest and nutrition (1g protein/lb, sleep > 7h). Continuing to stress the injury (heavy lifting, sports) extends timeline significantly.
| Peptide | Primary Action | Best For | Can Stack With Wolverine? |
|---|---|---|---|
| GHK-Cu | Collagen synthesis | Skin, Hair, Wound healing | Yes ✅ |
| ARA-290 | Nerve regeneration | Neuropathy, Nerve damage | Yes ✅ |
| Thymosin α1 | Immune modulation | Autoimmune GI issues | Yes ✅ |
| KPV | Anti-inflammatory | IBD, Colitis | Yes ✅ |
| LL-37 | Antimicrobial | SIBO, Infections | Yes ✅ |
Subject: Male, 38. Chronic knee pain (patellar tendinopathy) for 2 years. Failed PT, NSAIDs, cortisone shots.
Protocol: BPC-157 (250mcg local, near patellar tendon) 2x/day + TB-500 (2.5mg systemic) 2x/week for 6 weeks.
Result: Pain reduced 70% by week 3. Full function return by week 8. Returned to running at week 12.
Chronic injuries (2+ years) still respond to BPC/TB stack, but require patience (8-12 weeks). Local BPC injection near injury site appears more effective for tendons (anecdotal).
BPC-157 and TB-500 SIGNAL repair, but you must REST. Continuing to stress the injury (lifting heavy, running, sports) while on peptides is like hiring contractors but never letting them work. Results will be minimal.
Red welt (Injection Site Reaction) is NORMAL (histamine response). It resolves in 24-48 hours. Hot, spreading pus is NOT normal (infection). Seek medical attention immediately if infection suspected.
Some users feel great at week 2 and return to heavy activity. This causes re-injury. Follow the full protocol (6-8 weeks minimum) even if you feel healed. Remodeling phase is critical for long-term strength.
"Peptides represent one of the most promising frontiers in longevity medicine. When used thoughtfully and with proper monitoring, they can significantly enhance the body's natural repair mechanisms."
Longevity and peptide therapy
— The Drive Podcast #123"BPC-157 shows remarkable promise for injury healing, but the angiogenesis effects mean we must be cautious in those with any cancer history. Always consider the full biological picture."
Tissue repair and angiogenesis
— Huberman Lab Podcast"For any athlete, the 'Wolverine Stack' (BPC-157 + TB-500) is non-negotiable. I've seen tendon tears that were scheduled for surgery heal completely in 6 weeks. It changes the game for longevity."
Orthopedic peptide protocols
— SSRP Protocols"BPC-157 oral arginine salt is one of the most effective gut healing protocols I've seen. The gut-brain axis connection means fixing the gut can resolve issues throughout the body."
Gut health and systemic healing
— SSRP Protocols