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From 'The Natural Pulse' to 'The Nuclear Option'. Visualizing the hierarchy of GH interventions.
Not all GH interventions are created equal. Understanding where each falls on the potency scale helps in protocol design, risk management, and goal alignment. Choose the lowest effective dose.
The Natural Pulse (5-10% GH increase)
80% of GH is released during deep sleep. Optimize sleep hygiene for natural pulse.
16h fast triggers GH release as energy source. Especially effective when combined with sleep.
20min sauna post-workout can increase GH 2-3x for 2-3 hours. Acts as mild secretagogue.
Foundation for everyone. Required before any peptide protocol. Can't be skipped.
20-50% GH increase | Physiological pulse
First peptide protocol. For sleep quality, mild recovery, older adults (50+). Very safe, minimal side effects.
50-200% GH increase | Synergistic stacks
The synergistic stack. 100mcg each nightly.
Oral convenience. 20-25mg nightly. Major hunger trade-off.
Most potent GHRP. 100mcg 2x/week max. Rapid desensitization.
After mastering Level 2. For serious anti-aging, recovery, muscle preservation. Most common protocol for experienced users.
200-500% increase | Pharmaceutical grade
Recombinant human growth hormone. 2-4 IU daily (SubQ). Most potent option.
Insulin-like growth factor. 20-50mcg daily. Direct anabolic signal.
Only for elite athletes, serious bodybuilders, or medical necessity (GHD diagnosis). Requires physician oversight, regular bloodwork, and significant cost. NOT for general optimization.
→ Level 1 (Sleep Hygiene) + Level 2 (Ipamorelin 200mcg)
→ Level 2-3 (CJC/Ipa Stack 100/100mcg)
→ Level 3 (MK-677 20mg + Metformin)
→ Level 4 (rhGH) + Medical Supervision
Week 1-4: Master Level 1 (Sleep, Fasting, Sauna)
Week 5-12: Add Level 2 (Ipamorelin solo) → Assess response
Month 4+: Consider Level 3 (CJC/Ipa stack) if goals not met
Never: Skip to Level 4 without mastering 1-3
| Peptide | Potency | Dose | Cost/Month | Best For |
|---|---|---|---|---|
| Ipamorelin | Low | 200mcg | $50 | Sleep |
| Sermorelin | Low | 300mcg | $60 | Sleep (Older) |
| CJC/Ipa Stack | Moderate | 100/100mcg | $120 | Anti-Aging |
| Tesamorelin | High | 1mg | $200 | Fat Loss |
| MK-677 | High | 20mg | $80 | Mass (Trade-offs) |
| Hexarelin | Very High | 100mcg 2x/wk | $150 | Peak Performance |
| rhGH | Maximum | 2-4 IU | $800 | Elite/Medical |
NEVER skip levels. Each level builds on the previous. Skipping to Level 4 (rhGH) without mastering Levels 1-3 leads to poor outcomes, wasted money, and increased side effects.
Growth Hormone can accelerate tumor growth. DO NOT use any GH protocol (Level 2-4) if you have active cancer or are in remission (<5 years). Level 1 (Lifestyle) is safe and recommended.
Peptide protocols cost $50-200/month. rhGH costs $500-1000/month. Ensure you can sustain the cost for the full cycle duration (typically 8-16 weeks minimum).