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Clinical dosing tables, administration guidelines, and quick-reference protocols
Tendon/ligament injury, GI healing, neuroprotection
AM and PM, or near injury site
Inject near injury site when possible. Oral bioavailability ~10-15%. May combine with TB-500.
Systemic tissue repair, cardiac protection, hair growth
Any time, injection site not critical
Systemic action—injection site doesn't need to be near injury. Avoid in active malignancy (angiogenesis).
GH deficiency, anti-aging, recovery, sleep quality
Empty stomach, 30+ min before food. Optimal: before bed
Most selective GHRP. No significant cortisol/prolactin effects. Monitor IGF-1 (target 150-250).
GH optimization, synergy with GHRP
Empty stomach, combine with Ipamorelin
Combine with Ipamorelin for synergistic effect (10x GH release). Short half-life requires daily dosing.
Visceral adiposity, lipodystrophy, GH deficiency
AM, empty stomach
FDA-approved for HIV lipodystrophy. Superior visceral fat reduction. Check IGF-1 levels.
Obesity, T2DM, cardiovascular risk reduction
Same day each week, any time
Titrate slowly to minimize GI effects. CI in MEN2/MTC history. Monitor for pancreatitis symptoms.
Obesity, T2DM
Same day each week, any time
More effective than semaglutide for weight loss. Same GI titration needed. Check thyroid function.
Cognitive enhancement, neuroprotection, TBI, stroke recovery
AM and early PM. Avoid late dosing (may affect sleep)
Russian-approved drug. Upregulates BDNF. May enhance stimulant effects. Caution in mania-prone patients.
Anxiety, stress, cognitive support
AM and PM, or PRN for anxiety
No sedation or dependence. Modulates GABA. Excellent with Semax for balanced cognition.
Stroke, TBI, dementia, cognitive decline
Morning preferred
Porcine-derived. IV preferred for acute stroke. Level A evidence for dementia. CI in epilepsy, severe renal disease.
Hypoactive sexual desire disorder
45 minutes before anticipated sexual activity
FDA-approved for HSDD. Avoid >8 doses/month. May cause nausea (10%), hypertension (transient). CI: uncontrolled HTN.
Chronic infections, immunodeficiency, cancer adjuvant
Any time, consistent schedule
FDA orphan drug status. Used for HBV/HCV. May combine with checkpoint inhibitors in oncology.
| Test | Relevant Peptides | Target/Action Level | Frequency |
|---|---|---|---|
| IGF-1 | GH secretagogues | 150-250 ng/mL (anti-aging); <300 (safety) | Baseline, 4w, then q12w |
| HbA1c | GLP-1s, GH peptides | <5.7% (optimal); <6.5% (diabetic target) | Baseline, then q12w |
| Fasting Glucose | GH peptides, GLP-1s | 70-100 mg/dL; watch for ↑ with GH peptides | Baseline, 4w, then q8-12w |
| Lipase/Amylase | GLP-1 agonists | Normal limits; 3x ULN = concern | Baseline; PRN if symptoms |
| TSH | GLP-1s (theoretical MTC risk) | 0.5-4.0 mIU/L | Baseline, then annually |
| Renal Function | GLP-1s, Cerebrolysin | eGFR >30 for most peptides | Baseline, then q12w |
Insulin antagonizes GH. Dose GH secretagogues on empty stomach, 30+ minutes before eating. Bedtime dosing amplifies natural nocturnal GH pulse for optimal effect.
Slow titration over 4-8 weeks dramatically reduces GI side effects. If nausea persists, hold dose increase. Some patients plateau at lower doses with good effect.
Semax + Selank is synergistic: Semax for focus/BDNF, Selank for anxiolysis. Start with one, add the other after 1-2 weeks. Excellent for high-stress professionals.
BPC-157 (local) + TB-500 (systemic) covers both targeted and whole-body healing. BPC near injury site; TB-500 can be injected anywhere. Don't ice injuries—it delays healing.