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Establish a biological baseline to manage risk, not just treat disease.
The Big 5: ApoB (Heart), Insulin (Metabolic), Cystatin C (Kidney), hs-CRP (Inflammation), Free T (Hormonal).
Warning: Lab ranges are based on the average sick population. Do not accept "Normal" as "Healthy."
"Medicine 3.0 is not about treating disease after it appears. Its goal is to delay the onset of disease and maintain physical and cognitive function for as long as possible."
Imagine driving a Formula 1 car with a broken dashboard. Medicine 2.0 waits for the engine to explode (Heart Attack). Medicine 3.0 reads the telemetry (ApoB/Insulin) to prevent the explosion.
Cholesterol needs a boat to travel in blood. That boat is ApoB. Every particle that causes plaque carries exactly one ApoB molecule.
You can have "Low Cholesterol" (weight) but "High ApoB" (particle count). This is the most dangerous phenotype.
Hyperinsulinemia drives hypertension, cancer, and Alzheimer's. Insulin spikes 10 years before Glucose (HbA1c) rises.
| Biomarker | Standard Range | Medicine 3.0 Target |
|---|---|---|
| ApoB | < 100 mg/dL | < 60 mg/dL |
| Lp(a) | < 30 mg/dL | < 30 mg/dL |
| Trig/HDL Ratio | < 2.0 | < 1.0 |
| hs-CRP | < 3.0 | < 0.5 mg/L |
| Biomarker | Standard Range | Medicine 3.0 Target |
|---|---|---|
| Fasting Insulin | < 25 uIU/mL | 2 - 5 uIU/mL |
| HbA1c | < 5.7% | 4.8% - 5.1% |
| Uric Acid | < 7.0 | < 5.0 mg/dL |
| Homocysteine | < 15 | 6 - 9 umol/L |
| Biomarker | Standard Range | Medicine 3.0 Target |
|---|---|---|
| Free Testosterone | > 9 pg/mL | > 15-20 pg/mL |
| Estradiol (E2) | < 40 pg/mL | 20 - 35 pg/mL |
| TSH | 0.4 - 4.5 | 0.5 - 2.0 mIU/L |
| Cystatin C | < 1.0 | < 0.8 mg/L |
If you are ApoE4 (Hyper-responder), butter will spike your ApoB. Track it.
One bad night reduces insulin sensitivity by 30%. Do not test after a bender.
Stop 72hrs before blood draw. It falsifies TSH and Troponin results.
If Lp(a) > 50 mg/dL, diet cannot fix it. It is genetic. You are at high risk regardless of lifestyle. You must aggressively lower ApoB to < 40 mg/dL to compensate.
Fix Hypothyroidism (High TSH) before starting Statins. Low thyroid raises cholesterol artificially.
Analyze your IGF-1 levels relative to your age group.
Male, 38, CrossFit athlete, Paleo diet.
Felt great. "I don't need labs."
LDL was 180. ApoB was 140 (99th percentile). Lp(a) was 120 (Genetic Risk).
Despite 6-pack abs, he was building plaque at the rate of a 60-year-old due to genetics and saturated fat intake.
Started Ezetimibe + reduced butter. ApoB dropped to 60. Plaque progression stopped. He saved his own life by looking under the hood.
Male, 42, "Healthy".
Standard panel showed Cholesterol 180 (Normal). ApoB test revealed level of 120 (High Risk/Concordance).
Early intervention prevented potential calcium buildup and arterial damage.