14.7 Rapamycin (mTOR Inhibition)

The 'Crown Jewel' of longevity pharmacology. Weekly pulse dosing to trigger autophagy without starvation.

Longevity

Autophagy

mTOR

Life Extension

The Crown Jewel

Most validated lifespan-extending molecule in history (30% in mice). Weekly "pulse dosing" mimics caloric restriction (Autophagy) while maintaining muscle.

The Mechanism

mTOR Switch (Growth)Usually ON with food. Good for muscle, bad for aging (cancer/junk).

Autophagy (Cleanup)"Self-Eating". Scours cells for damaged proteins. Triggered by Rapamycin.

The "Pulse" Protocol

Dosage5-8mg Once Weekly
TimingSunday AM (Rest Day)
Hack: Take with fatty meal (Sardines/Avocado) to increase absorption by 30-50%.

The Weekly Cycle

Day 1: The Pulse

Take full dose. mTOR crashes. Massive Autophagy begins.

Day 2-3: Clearance

Drug clears system. Inhibition persists but fades.

Day 4-7: The Rebound

mTOR reactivates. Muscle protein synthesis restores. Immunity resets. Train hard now.

Side Effects

• Mouth Sores: Common (~20%). Treat with magic mouthwash. Do not stop.
• Lipid Elevation: May raise LDL/Trigs. Monitor ApoB.
• Infection Risk: Skip dose if you have active cold/flu.

Contraindications

• Under 30: You need mTOR for growth. Don't turn it off.
• Sarcopenic (Frail): Cannot afford to inhibit muscle.
• Surgery: Stop 2 weeks before. Wound healing requires mTOR.

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