Peptide Engine | The Complete Guide to Peptides, Biohacking & Longevity Medicine

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PEPTIDEENGINEBiohacking & Longevity

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📊 Key Metrics

Slope of Decline

Rate of testosterone drop per year. Critical for predicting hypogonadism timeline.

Example Calculation

Year 1: 650 ng/dL
Year 3: 580 ng/dL
Year 5: 510 ng/dL
→ -35 ng/dL/year

Action: If slope > -20 ng/dL/year, consider early intervention.

Inflammatory Velocity

Acceleration of systemic inflammation over time. Predicts cardiovascular and metabolic risk.

hs-CRP Trajectory

Baseline: 1.2 mg/L
+2 years: 2.1 mg/L
+4 years: 3.8 mg/L
→ 0.65 mg/L/year

Warning: Velocity > 0.5 mg/L/year indicates accelerating inflammation.

Kidney Aging Rate

eGFR decline trajectory. Predicts chronic kidney disease and longevity.

eGFR Decline

Age 40: 95 mL/min
Age 50: 88 mL/min
Age 60: 80 mL/min
→ -0.75/year

Normal: < 1.0/year. > 1.5/year requires intervention.

📅 Implementation Guide

Data Collection Requirements

Minimum 3 data points per biomarker (spaced 12+ months apart)
Same lab/testing methodology for consistency
Fasted state for metabolic markers
Consistent time of day for hormone panels

Calculating Trajectories

Use linear regression to calculate rate of change:

Slope = (Value_N - Value_1) / (Time_N - Time_1)

The Time Machine Algorithm

This proprietary model analyzes the rate of change in your biomarkers over the last 3-5 years to extrapolate your biological trajectory and predict future health outcomes.

📊 Key Metrics

Slope of Decline

Rate of testosterone drop per year. Critical for predicting hypogonadism timeline.

Example Calculation

Year 1: 650 ng/dL
Year 3: 580 ng/dL
Year 5: 510 ng/dL
→ -35 ng/dL/year

Action: If slope > -20 ng/dL/year, consider early intervention.

Inflammatory Velocity

Acceleration of systemic inflammation over time. Predicts cardiovascular and metabolic risk.

hs-CRP Trajectory

Baseline: 1.2 mg/L
+2 years: 2.1 mg/L
+4 years: 3.8 mg/L
→ 0.65 mg/L/year

Warning: Velocity > 0.5 mg/L/year indicates accelerating inflammation.

Kidney Aging Rate

eGFR decline trajectory. Predicts chronic kidney disease and longevity.

eGFR Decline

Age 40: 95 mL/min
Age 50: 88 mL/min
Age 60: 80 mL/min
→ -0.75/year

Normal: < 1.0/year. > 1.5/year requires intervention.

📅 Implementation Guide

Data Collection Requirements

Minimum 3 data points per biomarker (spaced 12+ months apart)
Same lab/testing methodology for consistency
Fasted state for metabolic markers
Consistent time of day for hormone panels

Calculating Trajectories

Use linear regression to calculate rate of change:

Slope = (Value_N - Value_1) / (Time_N - Time_1)

🔗 Related Tools & Resources

Bloodwork Time Machine

Interactive tool

Previous: Diagnostics

← Chapter 14.6

Next: Biomarker Tracking

Chapter 14.8 →

14.7 Advanced Diagnostics (The Bloodwork Time-Machine)

The Time Machine Algorithm

📊 Key Metrics

Slope of Decline

Inflammatory Velocity

Kidney Aging Rate

📅 Implementation Guide

Data Collection Requirements

Calculating Trajectories

🔗 Related Tools & Resources

14.7 Advanced Diagnostics (The Bloodwork Time-Machine)

The Time Machine Algorithm

📊 Key Metrics

Slope of Decline

Inflammatory Velocity

Kidney Aging Rate

📅 Implementation Guide

Data Collection Requirements

Calculating Trajectories

🔗 Related Tools & Resources