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PEPTIDEENGINEBiohacking & Longevity

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5.6 The 365-Day Optimization Calendar

Periodization is King. A master schedule for rotating between Build, Burn, and Repair.

Cycling

Longevity

Metabolism

Strategy

You cannot run every peptide, every day, forever. Receptors downregulate.

The body seeks homeostasis. We maximize results by rotating goals: Q1 (Detox), Q2 (Build), Q3 (Shred), Q4 (Repair).

Jan - Mar

Q1: The Clean Slate

FocusDetox & Insulin Sensitivity.

Core16:8 Fasting + Zone 2 Cardio.

Peptides

MOTS-c

SS-31

Apr - Jun

Q2: The Build

FocusHypertrophy & Strength.

CoreHeavy Lifting + Protein Surplus.

Peptides

CJC-1295

Ipamorelin

Jul - Sep

Q3: The Shred

FocusFat Loss & Definition.

CoreCaloric Deficit + HIIT.

Peptides

Tesofensine

5-Amino-1MQ

GLP-1

Oct - Dec

Q4: The Reset

FocusCognition, Immunity & Telomeres.

CoreSleep + Stress Reduction.

Peptides

Epitalon

Thymosin Alpha-1

The "Washout" Rule

Why cycle off?If you take GH secretagogues clearly for 365 days, your pituitary gland becomes "Deaf" to the signal (Tachyphylaxis).

For every 8 weeks ON, take 2 weeks OFF.
For every 6 months ON, take 1 month FULL DETOX.

The "Bridge" Myth

Do not "bridge" cycles with other peptides. If you come off CJC-1295 and immediately hop on MK-677, your Growth Hormone receptors never get a break. This leads to insulin resistance.

Real-Life Case Study: The Executive Year

Subject: 45yo Male, High Stress

Strategy:Alternated "Stimulation" (Q2/Q3) with "Repair" (Q1/Q4). Prioritized sleep in Q4.
Outcome:Maintained 12% body fat year-round. No burnout. Optimal blood markers.

"The magic is in the time OFF. If you don't cycle off, you are just renting a metabolism. Cycling off allows your body to 'own' the new set point."

— Jay Campbell

Expert Perspectives on Cycling Protocols

Ben Greenfield

Biohacker & Author

"The magic is in cycling off. Receptors downregulate when constantly stimulated. Periodization isn't just for training—it's for peptides too. Every 8 weeks on, 2 weeks off minimum."

Peptide cycling and receptor sensitivity

— Boundless (2020)

Dr. Andrew Huberman

Stanford Neuroscientist

"Peptide cycling isn't just about receptor downregulation—it's about maintaining your body's ability to respond. Constant stimulation leads to decreased sensitivity over time."

Peptide cycling and receptor sensitivity

— Huberman Lab Podcast

Loading dashboard...

5.6 The 365-Day Optimization Calendar

Periodization is King. A master schedule for rotating between Build, Burn, and Repair.

Cycling

Longevity

Metabolism

Strategy

You cannot run every peptide, every day, forever. Receptors downregulate.

The body seeks homeostasis. We maximize results by rotating goals: Q1 (Detox), Q2 (Build), Q3 (Shred), Q4 (Repair).

Jan - Mar

Q1: The Clean Slate

FocusDetox & Insulin Sensitivity.

Core16:8 Fasting + Zone 2 Cardio.

Peptides

MOTS-c

SS-31

Apr - Jun

Q2: The Build

FocusHypertrophy & Strength.

CoreHeavy Lifting + Protein Surplus.

Peptides

CJC-1295

Ipamorelin

Jul - Sep

Q3: The Shred

FocusFat Loss & Definition.

CoreCaloric Deficit + HIIT.

Peptides

Tesofensine

5-Amino-1MQ

GLP-1

Oct - Dec

Q4: The Reset

FocusCognition, Immunity & Telomeres.

CoreSleep + Stress Reduction.

Peptides

Epitalon

Thymosin Alpha-1

The "Washout" Rule

Why cycle off?If you take GH secretagogues clearly for 365 days, your pituitary gland becomes "Deaf" to the signal (Tachyphylaxis).

For every 8 weeks ON, take 2 weeks OFF.
For every 6 months ON, take 1 month FULL DETOX.

The "Bridge" Myth

Do not "bridge" cycles with other peptides. If you come off CJC-1295 and immediately hop on MK-677, your Growth Hormone receptors never get a break. This leads to insulin resistance.

Real-Life Case Study: The Executive Year

Subject: 45yo Male, High Stress

Strategy:Alternated "Stimulation" (Q2/Q3) with "Repair" (Q1/Q4). Prioritized sleep in Q4.
Outcome:Maintained 12% body fat year-round. No burnout. Optimal blood markers.

"The magic is in the time OFF. If you don't cycle off, you are just renting a metabolism. Cycling off allows your body to 'own' the new set point."

— Jay Campbell

Expert Perspectives on Cycling Protocols

Ben Greenfield

Biohacker & Author

"The magic is in cycling off. Receptors downregulate when constantly stimulated. Periodization isn't just for training—it's for peptides too. Every 8 weeks on, 2 weeks off minimum."

Peptide cycling and receptor sensitivity

— Boundless (2020)

Dr. Andrew Huberman

Stanford Neuroscientist

"Peptide cycling isn't just about receptor downregulation—it's about maintaining your body's ability to respond. Constant stimulation leads to decreased sensitivity over time."

Peptide cycling and receptor sensitivity

— Huberman Lab Podcast

Peptide Engine | The Complete Guide to Peptides, Biohacking & Longevity Medicine