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The 'mystical experience' as medicine: Promoting profound neural plasticity and depression remission.
Psilocybin is converted to psilocin, which activates 5-HT2A serotonin receptors. This produces profound alterations in consciousness ("mystical experience") and, crucially, rapid and lasting increases in neural plasticity.
at 4 weeks
(COMPASS, 2022)
at 6 months
(Johns Hopkins)
in drinking days
(NYU, 2022)
End-of-life care
(JHU/NYU)
Build therapeutic alliance, set intentions, discuss what to expect.
25mg psilocybin in a comfortable room, eyeshades, curated music playlist, 2 therapists present.
Process experience, extract insights, apply to daily life. This is where the real work happens.
"Research shows that therapeutic outcomes correlate strongly with the 'mystical' quality of the experience."
| Oregon & Colorado | Legal/Decriminalized | State-regulated healing centers active. |
| Australia | Medical Approval | TGA-approved for treatment-resistant depression. |
| FDA (USA) | Breakthrough Therapy | Phase 3 trials ongoing. Expected approval post-MDMA. |