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Where Experts Disagree. Conflict Resolution Logic for Cholesterol, Meat, Cold, and Sleep.
Science is rarely settled. These debates define modern biohacking. The goal is not to find who is "right," but to find which philosophy matches your risk tolerance and biological data.
ApoB < 30-40. Statins/PCSK9 are tools to stop vascular aging. Chemical intervention often necessary.
High LDL ok if inflammation/insulin low (Lean Mass Hyper-Responder). Diet first.
Vascular aging must be stopped. Statin + Ezetimibe immediately. Zero tolerance.
Bioavailable Leucine needed for muscle synthesis. Sarcopenia is the enemy.
Meat spikes IGF-1 (Aging/Cancer). Uses Vegan diet + precise Amino Acids.
"Pegan". Beef is health food but should be 25% of plate (side dish), not center.
Dopamine 2.5x. Brown fat activation. Mental resilience.
Marginal benefit vs sleep/exercise. Cortisol spike. Not a 'longevity' drug.
Cools bed for sleep, but avoids shock unless data supports inflammation reduction.
ApoB 120+? Attia wins (Drugs). ApoB 60? Hyman wins (Lifestyle).
Bodybuilder? Huberman (Meat). Live to 120? Johnson (Vegan).
No universal answers. Test, don't guess.
Ideology kills. If you are a "Carnivore" with ApoB 200, you are ignoring data. If "Vegan" gives you sarcopenia, you are ignoring biology. Be agnostic. Follow biomarkers, not tribes.
"Lab reference ranges are designed to catch disease, not optimize healthspan. If your ApoB is 90, your doctor will say you're fine. But you're not—you're aging faster than necessary."
Bloodwork interpretation
— Outlive (2023)