What are peptides and how do they work?

Peptides are short chains of amino acids that act as signaling molecules in the body. They bind to specific receptors to trigger biological responses, making them powerful tools for health optimization and disease treatment.

When used properly under medical supervision, peptides are generally safe. However, they can have side effects and interactions with other medications. Always consult with a qualified healthcare provider before starting any peptide protocol.

How are peptides administered?

Most therapeutic peptides are administered via subcutaneous injection. Some peptides can be taken orally or applied topically, depending on their formulation and intended use.

What conditions can peptides help with?

Peptides can help with various conditions including injury recovery, cognitive enhancement, weight management, immune system support, hormonal optimization, and anti-aging.

Do peptides require a prescription?

Many therapeutic peptides require a prescription and should only be used under medical supervision. Some peptides are available over-the-counter, but professional guidance is still recommended.

Peptide Engine | The Complete Guide to Peptides, Biohacking & Longevity Medicine

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The "Furnace" Effect

Semaglutide lifts your foot off the gas (Appetite). Retatrutide does that AND revs the engine at idle. The addition of Glucagon agonism actively increases Resting Metabolic Rate.

The Hierarchy (2026)

The King

Retatrutide

Triple Agonist (GLP-1 / GIP / GCG)

• Potency: ~24-29% Weight Loss.
• Mechanism: Increases energy expenditure via Glucagon.
• Risk: High Heart Rate, Muscle Loss, Dysesthesia (Skin Pain).

The Shield

CagriSema

Amylin + GLP-1

• Potency: ~25% Weight Loss.
• Mechanism: Massive satiety without cardiac stress.
• Best For: Anxiety prone, Insomniacs, Heart issues.

The Muscle Tax

The sheer speed of weight loss (~30% in a year) puts you at extreme risk for sarcopenia (muscle loss). You CANNOT run these agents without the following:

1g / lbProtein Target (Non-negotiable)

3x / wkHeavy Resistance Training

DEXAScan every 6 months

Dysesthesia (Skin Pain)

Unique to Retatrutide. "Sunburn sensation" without sun. Neurological side effect of GIP/GCG. Usually fades.

Cardiac Drift

Resting Heart Rate will increase 5-10bpm. This will show as "Stress" on wearables. Normal for this class.

Knowledge Base

13.9 The Metabolic Titans (Triple Agonists)

The "Furnace" Effect

The Hierarchy (2026)

Retatrutide

CagriSema

The Muscle Tax

Dysesthesia (Skin Pain)

Cardiac Drift

13.9 The Metabolic Titans (Triple Agonists)

The "Furnace" Effect

The Hierarchy (2026)

Retatrutide

CagriSema

The Muscle Tax

Dysesthesia (Skin Pain)

Cardiac Drift