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Analysing Fuel Partitioning: Lipolysis vs Oxidation.
Metabolic optimization is not just about "burning calories." It is about fixing the Fuel Partitioning.
We want to force the body to release stored energy (Lipolysis) and burn it (Oxidation) while preserving the engine (Muscle).
Most diets fail because the body fights back. It lowers the "Thermostat" (Metabolic Rate) to save energy.
Rapid weight loss often strips muscle. You must eat 1g protein/lb and lift weights, or you will end up "Skinny Fat."
GLP-1s cost $500+. Strategy: If budget is tight, start with Tesofensine (~$150) or 5-Amino-1MQ.
Verdict: Use GLP-1 for mass reduction. Use Tesofensine for body sculpting.
"GLP-1 agonists are arguably the most impactful drugs of the century, but if you lose muscle while on them, you are trading diabetes for frailty. Resistance training is not optional."
Metabolic health and muscle preservation
— Outlive (2023)"If you're on a GLP-1 agonist and not doing resistance training, you're trading metabolic health for frailty. Muscle loss on these drugs is real and preventable with proper training."
GLP-1 agonists and muscle preservation
— The Drive Podcast"The next generation of metabolic therapeutics will be triple agonists like Retatrutide. Combining GLP-1, GIP, and Glucagon activation addresses multiple pathways simultaneously—not just appetite suppression, but actual metabolic rate enhancement."
Future of metabolic therapeutics
— The Drive Podcast