Loading...
Loading...
Beyond Calories. Targeting mitochondria to simulate the metabolic effects of exercise and fasting.
The Furnace Analogy.
The Spark: A signal usually released during heavy squats. Tricks body into "Post-Workout Mode."
Mechanism: Blocks NNMT enzyme. Forces "lazy" fat cells to mobilize. Bonus: Raises NAD+.
Aggressive Recomposition.
| Agent | Dose | Role |
|---|---|---|
| Tirzepatide | 2.5mg/wk | Control Hunger |
| MOTS-c | 5mg/wk | Increase Burn |
| 5-Amino-1MQ | 100mg/day | Unlock Fat Cells |
| Tesofensine | 250mcg/day | Dopamine Tone |
The "Sidekick": 5-Amino-1MQ is not a stimulant (like Caffeine) or a hormone.
It effectively "releases the parking brake" on your metabolism.
5-Amino-1MQ is expensive ($150-200/month).
Fix: Use only during aggressive 4-6 week cut phases."GLP-1 agonists are arguably the most impactful drugs of the century, but if you lose muscle while on them, you are trading diabetes for frailty. Resistance training is not optional."
Metabolic health and muscle preservation
— Outlive (2023)"If you're on a GLP-1 agonist and not doing resistance training, you're trading metabolic health for frailty. Muscle loss on these drugs is real and preventable with proper training."
GLP-1 agonists and muscle preservation
— The Drive Podcast"The next generation of metabolic therapeutics will be triple agonists like Retatrutide. Combining GLP-1, GIP, and Glucagon activation addresses multiple pathways simultaneously—not just appetite suppression, but actual metabolic rate enhancement."
Future of metabolic therapeutics
— The Drive Podcast