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Analysis: The 'Zombie Cell' Hunter. Force senescent cells to apoptosis so fresh stem cells can replace them.
Senescent cells are old cells that refuse to die. They sit in your tissues and secrete inflammatory toxic sludge (SASP).
Senolytics are agents that force these zombies to commit suicide (Apoptosis) so fresh stem cells can replace them.
The Analogy: One rotten apple spoils the barrel.
A senescent cell is a rotten apple. It releases chemicals (SASP) that turn neighboring healthy cells into zombies too. If you don't remove them, the rot spreads.
Fisetin (2000mg) + Quercetin (1000mg). High dose is key to trigger apoptosis.
Repeat dose. Ensure all weakened zombies are finished off.
STOP taking them. Taking antioxidants daily blunts the body's natural cleanup signal (ROS). Rest and Restore.
Fisetin powder is poorly absorbed (like eating sand).
You MUST use:
Herxheimer Reaction: When senescent cells die, they release debris.
You may feel "flu-like" symptoms, fatigue, or brain fog for 24-48 hours. This means it is working.
Hydrate vigorously.
60yo Male, Knee Arthritis - Chronic stiffness, unable to squat. High hsCRP (3.5).
Chronic stiffness, unable to squat. hsCRP: 3.5 (elevated)
High inflammatory burden
Dasatinib (100mg) + Quercetin (1000mg) for 2 days (Mayo Protocol)
Hit-and-run senolytic strike
"Flu-like" symptoms for 24h (senescent cell die-off response)
Normal immune response to cell clearance
Pain reduced 60%. hsCRP dropped to 1.1 (normal range)
Significant inflammation reduction
Joint mobility improved. Able to squat with minimal discomfort
Functional improvement achieved
Successful senescent cell clearance with dramatic reduction in inflammatory markers and pain
Q: Why can't I take Quercetin every day?
For Senolysis (killing zombie cells), you need a massive spike in concentration (Hit & Run). Chronic antioxidants blunt the body's natural cleanup signals.
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