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GLP-1 + GIP + Glucagon: The most potent metabolic agent in development with unprecedented weight loss results
Think of weight loss medications like hiring employees to help you lose weight:
The "Appetite Manager" - Makes you feel full, reduces cravings
Found in: Semaglutide, Tirzepatide
The "Insulin Helper" - Improves how your body uses glucose
Found in: Tirzepatide only
The "Fat Burner" - Actually BURNS stored fat for energy
Found in: Retatrutide only!
The Breakthrough: Retatrutide is the first to combine all three. You eat less (GLP-1), process food better (GIP), AND actively burn more fat (Glucagon). Triple threat.
| Dose (Weekly) | 24-Week Weight Loss | 48-Week Weight Loss | % Achieving ≥15% Loss |
|---|---|---|---|
| Placebo | -2.1% | -2.1% | 3% |
| 1 mg | -8.7% | -8.9% | 12% |
| 4 mg | -17.1% | -17.4% | 54% |
| 8 mg | -22.1% | -22.8% | 71% |
| 12 mg | -24.2% | -24.2% | 83% |
Study: N = 338 adults with obesity (BMI ≥30) or overweight (BMI ≥27) with comorbidity. 48-week treatment period.
Reference: Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.
Semaglutide (Wegovy)
~15%
68 weeks
Tirzepatide (Zepbound)
~21%
72 weeks
Retatrutide
~24%
48 weeks
This is why Retatrutide shows more weight loss: While GLP-1/GIP reduce food intake, glucagon actually increases energy expenditure. You're burning more calories even at rest.
Retatrutide is NOT currently available outside of clinical trials. Information here is based on published Phase 2 data and represents expected clinical profile. Do not attempt to obtain.
"The GLP-1 agonists like semaglutide are remarkable not just for weight loss, but for their effects on the brain's reward circuitry. They fundamentally change the relationship with food by modulating dopamine signaling."
Dr. Andrew Huberman
Professor of Neurobiology
"When we look at the data on GLP-1 agonists, we're seeing something unprecedented in obesity medicine—sustained weight loss of 15-20% with cardiovascular benefit. This is a paradigm shift."
Dr. Peter Attia
Physician & Longevity Expert